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Guccini et al. show that TIMP1 loss switches senescence from a tumor-suppressive to a pro-metastatic process in prostate cancer mouse models. Pharmacological targeting of TIMP1-deficient senescent tumor cells impedes metastases in mice, thereby validating the therapeutic potential of senolytic therapy in prostate cancer. Capuldi excel
National Heart, Lung, and Blood Institute National Institutes of Health Available Funding and Operating Guidelines Goals. The National Heart, Lung, and Blood Institute (NHLBI) applies NIH cost management guidelines when making FY2020 grant awards (see NOT-OD-20-068).Legislative mandates for FY2020 are in effect (see NOT-OD-20-066).The salary limitation set at Executive Level II of the Federal ...

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F31, 33, 35: “Final 3” social problems “Days of conflict” also refers to confrontational actions, such as yelling, fighting, physical/verbal abuse, and loss of control F33. Refers to social problems that are defined by ASI questions not related to family F31-F35. Include feelings of loneliness, dissatisfaction with friends, etc.

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Adjustment for SES factors did not meaningfully affect the risk estimate. Higher risk estimates were observed among participants living in low-SES neighborhoods. The most and least disadvantaged quartiles of the NSES score had HRs of 1.39 (95% CI: 1.21, 1.61) and 0.90 (95% CI: 0.72, 1.07), respectively.

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code assignment should be based on the lowest GCS score, that is, the most severe level of consciousness ... (F31–F33) • dissociative (F44.2) ... affect on the ...

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Inflammatory markers and the Center for Epidemiologic Studies-Depression scale [total score: CES-D total and four distinctive domains: somatic complaints, depressed affect, positive affect and interpersonal problems] were examined among African-American (AA) and White urban adults participating in the Healthy Aging in Neighborhoods of Diversity ...

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Fellowship designed specifically to support outstanding scientific training for graduating predoctoral and postdoctoral fellows who will begin or are just beginning a new postdoctoral training period in a given laboratory or research environment.

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